To Exit or Not To Exit: That is the Question. To Build or Retreat: That is Another Question

coeliac disease: to classify or not to classify – that is the question!

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To scavenge or not to scavenge: that is the question.

Analysis of a series of diffraction data sets measured from four native as well as four nicotinic acid-soaked crystals of trypsin at 100 K shows a high variability in radiation-sensitivity among individual crystals for both nicotinic acid-soaked and native crystals. The level of radiation-sensitivity and the extent of its variability is statistically indistinguishable between the two conditions...

To P or not to P: that is the question.

In 1993 Eugene Harris, a well-known biostatistician at the NIH, wrote an editorial for Clinical Chemistry regarding the use of P values vs confidence intervals in the evaluation of scientific data (1 ). This has long been a contentious topic in the scientific world and one with which each new generation of scientists has had to grapple on the basis of arguments advanced for the use of various s...

To Code or Not to Code, That Is the Question

To T or not to T, that is the question.

The quest for a test that is absolutely disease-and tissue-specific could be considered the Holy Grail of the clinical chemist, dreamt of but seldom achieved. Initial reports on measurement of the cardiac troponins, cardiac troponin T (cTnT) and cardiac troponin I (cTnI), for diagnosis of myocardial infarction suggested that these markers would become the " gold standard, " replacing all other ...